Cartilage degeneration, characterized by collagen structure disruption, proteoglycan depletion, and increased water content, has been shown to alter T2 and T1ρ relaxation times. A composite metric, R2-R1ρ, which further reflects an anisotropic component of R2, has recently demonstrated high sensitivity to cartilage degeneration; however, quantification of R2 and R1ρ respectively requires long scan times. In this work, we validated the potential of assessing R2-R1ρ using one pair of signals with T1ρ preparation and T2 preparation from a combined T1ρ/T2 quantification sequence for in vivo knee MRI at 3T.
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