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Abstract #1165

Efficient Measurement of Composite Metric R2-R1ρ in Knee Cartilage 

Misung Han1, Radhika Tibrewala1, Emma Bahroos1, Valentina Pedoia1,2, and Sharmila Majumdar1,2
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Center for Digital Health Innovation, University of California, San Francisco, San Francisco, CA, United States

Cartilage degeneration, characterized by collagen structure disruption, proteoglycan depletion, and increased water content, has been shown to alter T2 and Trelaxation times. A composite metric, R2-R, which further reflects an anisotropic component of R2, has recently demonstrated high sensitivity to cartilage degeneration; however, quantification of R2 and Rrespectively requires long scan times. In this work, we validated the potential of assessing R2-Rusing one pair of signals with Tpreparation and T2 preparation from a combined T/T2 quantification sequence for in vivo knee MRI at 3T.

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