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Abstract #1171

Ex vivo MRI template of the human cervical cord at 80μm isotropic resolution

Charley Gros1, Abdullah Asiri2,3, Benjamin De Leener4, Charles Watson5, Gary Cowin6, Marc Ruitenberg7, Nyoman Kurniawan2, and Julien Cohen-Adad1,8
1NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 3Radiology department, College of applied medical sciences, Najran University, Najran, Saudi Arabia, 4Department of Computer and Software Engineering, Polytechnique Montreal, Montreal, QC, Canada, 5Faculty of Health Sciences, Curtin University of Technology, Perth, Australia, 6National Imaging Facility, Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 7School of Biomedical Sciences, The University of Queensland, Brisbane, Australia, 8Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada

Spinal cord MRI templates allow reproducible and large scale atlas-based studies. However, current templates may have suboptimal resolutions (~0.5mm isotropic) to analyse high resolution data acquired at ultra-high field (e.g. 7T scanners). We generated a 3D human cervical cord template at 80µm isotropic resolution, from 13 ex vivo specimens, with a reference based on spinal levels. Further, the template was registered to the existing in vivo PAM50 template. Results showed consistency with histological studies in terms of grey matter morphology, and template generation achieved high accuracy (mean distance error: 0.10±0.01mm). The template and related scripts will be made publicly available.

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