Abstract #1178

Sodium concentration alterations in spinal cord injury and associations to motor and sensory function

Bhavana Shantilal Solanky¹, Ferran Prados¹, Carmen Tur¹, Selma Al-Ahmad², Xixi Yang¹, Baris Kanber³, David Choi², Jalesh N Panicker⁴, and Claudia A M Gandini Wheeler-Kingshott¹

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, United Kingdom, ²National Hospital For Neurology and Neurosurgery, Queen Square, London, United Kingdom, ³Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁴Department of Uro-neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom

Sodium retention as a consequence of spinal cord injury is thought to impair the regenerative ability of neurons but also reduce damage. Studies have shown that sodium-blockers can lead to improved outcomes in some SCI patients. Here alterations in spinal cord total sodium concentrations in spinal cord injury patients and healthy controls were investigated using sodium MRS. The association of sodium concentration to cross sectional area and ASIA score was also explored.

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