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Abstract #1178

Sodium concentration alterations in spinal cord injury and associations to motor and sensory function

Bhavana Shantilal Solanky1, Ferran Prados1, Carmen Tur1, Selma Al-Ahmad2, Xixi Yang1, Baris Kanber3, David Choi2, Jalesh N Panicker4, and Claudia A M Gandini Wheeler-Kingshott1
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, United Kingdom, 2National Hospital For Neurology and Neurosurgery, Queen Square, London, United Kingdom, 3Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 4Department of Uro-neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom

Sodium retention as a consequence of spinal cord injury is thought to impair the regenerative ability of neurons but also reduce damage. Studies have shown that sodium-blockers can lead to improved outcomes in some SCI patients. Here alterations in spinal cord total sodium concentrations in spinal cord injury patients and healthy controls were investigated using sodium MRS. The association of sodium concentration to cross sectional area and ASIA score was also explored.

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