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Abstract #1199

Evaluation of potential hemodynamic biomarkers in experimental PAH using center-out stack-of-stars 4D phase contrast velocity mapping

Ali Nahardani1,2, Simon Leistikow2,3, Katja Grün4, Martin Krämer1, Karl Heinz Herrmann1, Andrea Schrepper5, Reinhard Bauer6, Christian Jung7, Alexander Berndt8, P. Christian Schulze4, Lars Linsen3, Jürgen R. Reichenbach1, Marcus Franz4, and Verena Hoerr1,2,9
1Institute of Diagnostic and Interventional Radiology, Medical Physics Group, University Hospital Jena, Jena, Germany, 2Institute of Medical Microbiology, University Hospital Jena, Jena, Germany, 3Institute of Computer Science, Department of Mathematics and Computer Science, Westfälische Wilhelms-Universität Münster, Muenster, Germany, 4Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, University Hospital Jena, Jena, Germany, 5Department of Cardiothoracic Surgery, University Hospital Jena, Jena, Germany, 6Institute of Molecular Cell Biology, Center of Molecular Biomedicine, University Hospital Jena, Jena, Germany, 7Department of Internal Medicine, Division of Cardiology, University Hospital Düsseldorf, Düsseldorf, Germany, 8Institute of Legal Medicine, Section of Pathology, University Hospital Jena, Jena, Germany, 9Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany

Potential hemodynamic biomarkers of pulmonary arterial hypertension (PAH) and consecutive right ventricular remodeling were investigated by 4D flow center-out stack-of-stars velocity mapping in a rat model of monocrotaline induced PAH in comparison to healthy controls and a treatment group taking Macitentan. The averaged-mean values of blood flow velocities of pulmonary tract were substantially decreased in the diseased animal group compared to the control and under-treatment group. Diseased animals further showed a pronounced pressure gradient drop between the pulmonary artery bronchial branches and pulmonary veins. The effect of vascular resistance was additionally noted in the velocity-time curve of the pulmonary arteries.

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