Abstract #1199

Evaluation of potential hemodynamic biomarkers in experimental PAH using center-out stack-of-stars 4D phase contrast velocity mapping

Ali Nahardani^1,2, Simon Leistikow^2,3, Katja Grün⁴, Martin Krämer¹, Karl Heinz Herrmann¹, Andrea Schrepper⁵, Reinhard Bauer⁶, Christian Jung⁷, Alexander Berndt⁸, P. Christian Schulze⁴, Lars Linsen³, Jürgen R. Reichenbach¹, Marcus Franz⁴, and Verena Hoerr^1,2,9

¹Institute of Diagnostic and Interventional Radiology, Medical Physics Group, University Hospital Jena, Jena, Germany, ²Institute of Medical Microbiology, University Hospital Jena, Jena, Germany, ³Institute of Computer Science, Department of Mathematics and Computer Science, Westfälische Wilhelms-Universität Münster, Muenster, Germany, ⁴Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, University Hospital Jena, Jena, Germany, ⁵Department of Cardiothoracic Surgery, University Hospital Jena, Jena, Germany, ⁶Institute of Molecular Cell Biology, Center of Molecular Biomedicine, University Hospital Jena, Jena, Germany, ⁷Department of Internal Medicine, Division of Cardiology, University Hospital Düsseldorf, Düsseldorf, Germany, ⁸Institute of Legal Medicine, Section of Pathology, University Hospital Jena, Jena, Germany, ⁹Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany

Potential hemodynamic biomarkers of pulmonary arterial hypertension (PAH) and consecutive right ventricular remodeling were investigated by 4D flow center-out stack-of-stars velocity mapping in a rat model of monocrotaline induced PAH in comparison to healthy controls and a treatment group taking Macitentan. The averaged-mean values of blood flow velocities of pulmonary tract were substantially decreased in the diseased animal group compared to the control and under-treatment group. Diseased animals further showed a pronounced pressure gradient drop between the pulmonary artery bronchial branches and pulmonary veins. The effect of vascular resistance was additionally noted in the velocity-time curve of the pulmonary arteries.

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