Abstract #1206

CrCEST energetics of calf muscle groups at 3T distinguish patients with peripheral arterial disease from age-matched normals

Helen Sporkin¹, Christopher Schumann², Roshin Mathew², Christopher Kramer^2,3, and Craig Meyer^1,3

¹Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ²Cardiology, University of Virginia, Charlottesville, VA, United States, ³Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States

In Peripheral Arterial Disease, arterial occlusions in the lower limbs lead to tissue ischemia, which can lead to claudication pain or the need for amputation. Creatine CEST (CrCEST) imaging can indirectly image creatine as it exchanges protons with free water during metabolism after exercise. Ischemia in the skeletal reduces available oxygen, slowing metabolism. CrCEST data of three major calf muscle groups were fit to a monoexponential function in order to compare energetics between PAD patients and age-matched normal subjects. We have so far imaged 22 aged-matched subjects and 19 PAD patients, and found a significant increase in the decay constant.

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