Abstract #1210

Assessing lung perfusion in pulmonary hypertension

Paul J.C. Hughes¹, Andrew J. Swift^1,2, Frederick J. Wilson³, Marcella Cogliano¹, Fasial AA Alandejani¹, Anthony Cahn³, Lindsay Kendall³, David G. Kiely^2,4,5, and Jim M. Wild^1,2

¹POLARIS, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, ²Insigneo Institute for in silico Medicine, The University of Sheffield, Sheffield, United Kingdom, ³GlaxoSmithKline R&D Ltd, Stevenage, United Kingdom, ⁴Sheffield Pulmonary Vascular Disease, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom, ⁵Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom

Pulmonary arterial hypertension (PAH) is a condition that impacts on lug perfusion and right ventricular function. This work aimed to assess i) the diagnostic utility of relative pulmonary perfusion parameters to distinguish patients with PAH from healthy controls and ii) changes in lung perfusion in 2 patient groups with PAH: newly diagnosed patients initiating and patients escalating treatment and clinically stable patients who had no escalation of treatment.

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