Abstract #1234

A magnetization transfer weighted anatomical reference allows laminar fMRI analysis in native functional image space

Yuhui Chai¹, Linqing Li², Yicun Wang³, Larentius Huber⁴, Benedikt Poser⁴, Jeff Duyn³, and Peter Bandettini^1,2

¹Section on Functional Imaging Methods, Laboratory of Brain and Cognition, NIMH, NIH, Bethesda, MD, United States, ²Functional MRI Core, NIMH, NIH, Bethesda, MD, United States, ³Advanced MRI Section, Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD, United States, ⁴Maastricht Brain Imaging Center, Faculty of Psychology and Neuroscience, University of Maastricht, Maastricht, Netherlands

In most previous laminar fMRI studies, cortical layers are defined based on an anatomical image that is collected by a different acquisition technique and exhibits different geometric distortion compared to the functional images. We introduce to generate a magnetization transfer (MT) weighted anatomical reference, using identical acquisition design as fMRI measurement. Cortical surface and depth can be reconstructed directly from this MT-weighted anatomical EPI image and all laminar analysis can be performed in the native fMRI image space without the need for distortion correction and registration.

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