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Abstract #1237

Disrupted Small-World Networks and Differences in Metabolite Concentration in Healthy Adults with Low and High Genetic Risk

Hui Zhang1,2, Pui Wai Chiu1,3, Isaac Ip4, Tianyin Liu5, Gloria Hoi Yan Wong5, You-Qiang Song6, Savio Wai Ho Wong4, Queenie Chan7, Karl Herrup8, and Henry Ka Fung Mak1,2,3
1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Alzheimer's Disease Research Network, Hong Kong, Hong Kong, 3State Key Laboratory of Brain and Cognitive Sciences, Hong Kong, Hong Kong, 4Department of Educational Psychology, the Chinese University of Hong Kong, Hong Kong, Hong Kong, 5Department of Social Work and Administration, The University of Hong Kong, Hong Kong, Hong Kong, 6Department of Biochemistry, The University of Hong Kong, Hong Kong, Hong Kong, 7Philips Healthcare, Hong Kong, Hong Kong, 8Alzheimer Disease Research Centre, University of Pittsburgh, Pittsburgh, PA, United States

To identify the relationship between the topological properties and glutamate in genetic-related subgroups (ApoE4 carriers and non-ApoE4 carriers), combined resting state fMRI (rs-fMRI) and MRS were applied in this study. Graph theory metrics of subgroups were calculated and compared. In the results, ApoE4 carriers had worse network segregation and integration. However, there was significant correlation between [Glx]abs in left hippocampus and topological metrics in high-risk group. We postulated that glutamatergic synaptic transmission modulates rs-fMRI activities in ApoE4 carriers.

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