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Abstract #1248

Comparing stimulus and resting state fMRI at 3T and 7T reveal a superiority of 7T in detecting changes in subcortical networks

Silke Kreitz1,2, Angelika Mennecke1, Laura Cristina Konerth 2, Armin Nagel3, Frederic Laun3, Michael Uder3, Arnd Doerfler1, and Andreas Hess2
1Department of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany, 2Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nurnberg, Erlangen, Germany, 3Department of Radiology, University Hospital of the Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

7T MRI is hoped to improve diagnostics, therapy and research of neurological diseases. Here, we characterize the influence of field strength on fMRI approaches including task based and RS-fMRI. Quality metrics revealed a basic separation of 3T and 7T fMRI data, mainly by tSNR, MDI, CNR and EFC. 7T fMRI showed higher BOLD response amplitudes, more functional connections and higher connectivity strength especially in inferior brain regions. Though higher variability between subjects at 7T likely requires enhanced statistical power in group comparisons, intra individual fMRI measurements might detect subtle connectivity changes at 7T useful for diagnosis and therapy.

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