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Abstract #1267

A deflectable positionally-localized Virtual Biopsy “Gun”: Construct and initial testing

Ehud J Schmidt1,2, Yue Chen3, Anthony Gunderman3, Junichi Tokuda4, Hassan Elahi5, Ravi T Seethamraju6, Henry R Halperin5, and Akila N Viswanathan2
1Medicine (Cardiology), The Johns Hopkins University, Baltimore, MD, United States, 2Radiation Oncology, Johns Hopkins University, Baltimore, MD, United States, 3Mechanical Engineering, University of Arkansas, Fayetteville, AR, United States, 4Radiology, Brigham and Womens Hospital, Boston, MA, United States, 5Medicine (Cardiology), Johns Hopkins University, Baltimore, MD, United States, 6MRI, Siemens Healthineers, Boston, MA, United States

Evaluating tissue properties prior-to or during therapy, such as locating cancerous and necrotic cells, or characterizing response to radiation or ablation, is conventionally performed by tissue excision, followed by pathologic examination. An alternative is diagnosing tissue in-situ without removing it, as performed using Optical-Coherence-Tomography or Intra-Vascular-UltraSound. We aim to perform tissue definition in soft-tissues not accessed through body-orifices or blood-vessels by combining; (1) Steerable tissue-puncture, (2) MR-Tracking-motion-localization, and (3) imaging along the punctured-holes' walls. Utilization requires rapid high-CNR multiple-contrast MRI. A deflectable virtual-biopsy “gun” for diagnosing cervical-cancer radiation-therapy response was developed. It imaged ~15mm surrounding punctured-holes created for brachytherapy seed-delivery.

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