Abstract #1267

A deflectable positionally-localized Virtual Biopsy “Gun”: Construct and initial testing

Ehud J Schmidt^1,2, Yue Chen³, Anthony Gunderman³, Junichi Tokuda⁴, Hassan Elahi⁵, Ravi T Seethamraju⁶, Henry R Halperin⁵, and Akila N Viswanathan²

¹Medicine (Cardiology), The Johns Hopkins University, Baltimore, MD, United States, ²Radiation Oncology, Johns Hopkins University, Baltimore, MD, United States, ³Mechanical Engineering, University of Arkansas, Fayetteville, AR, United States, ⁴Radiology, Brigham and Womens Hospital, Boston, MA, United States, ⁵Medicine (Cardiology), Johns Hopkins University, Baltimore, MD, United States, ⁶MRI, Siemens Healthineers, Boston, MA, United States

Evaluating tissue properties prior-to or during therapy, such as locating cancerous and necrotic cells, or characterizing response to radiation or ablation, is conventionally performed by tissue excision, followed by pathologic examination. An alternative is diagnosing tissue in-situ without removing it, as performed using Optical-Coherence-Tomography or Intra-Vascular-UltraSound. We aim to perform tissue definition in soft-tissues not accessed through body-orifices or blood-vessels by combining; (1) Steerable tissue-puncture, (2) MR-Tracking-motion-localization, and (3) imaging along the punctured-holes' walls. Utilization requires rapid high-CNR multiple-contrast MRI. A deflectable virtual-biopsy “gun” for diagnosing cervical-cancer radiation-therapy response was developed. It imaged ~15mm surrounding punctured-holes created for brachytherapy seed-delivery.

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