A huge amount of T2-FLAIR images with appearance of white matter hyperintencities (WMH) were used. 1368 cases from one hospital were selected as the training set. Another 100 cases from the same hospital and 200 cases from the other 2 different hospitals were treated as the independent test set. Based on multi-class U-SegNet approach, it can achieve the highest F1 score (same hospital: 90.01%; different hospital: 86.52%) in the test set compared with other approaches. The result suggested that the multi-class segmentation approach is more resilient to the variations of MR image parameters than the single label segmentation approach.