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Abstract #1315

High-Resolution Free-Breathing Quantitative Myocardial Perfusion MRI Using Multi-Echo Dixon

Joao Tourais1,2, Torben Schneider3, Cian Scannell4, Russell Franks4, Javier Sanchez-Gonzalez5, Mariya Doneva6, Christophe Schuelke6, Jakob Meineke6, Jochen Keupp6, Jouke Smink1, Marcel Breeuwer1,2, Amedeo Chiribiri4, Markus Henningsson7, and Teresa Correia4
1MR R&D – Clinical Science, Philips Healthcare, Best, Netherlands, 2Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Philips Healthcare, Guildford, Surrey, United Kingdom, 4School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 5Philips Healthcare Iberia, Madrid, Spain, 6Philips Research Europe, Hamburg, Germany, 7Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden

First-pass perfusion cardiac MR (FP-CMR) allows the detection of myocardial ischemia. Also, quantitative methods enable a reliable and operator-independent assessment of myocardial perfusion. However, conventional FP-CMR has limited spatial resolution and should be performed under breath-hold. Therefore, diagnostic accuracy is compromised by respiratory induced motion artifacts and false-positive defects due to dark-rim artifacts. We propose, a k-t accelerated dual-saturation FP-CMR multi-echo Dixon sequence to increase the spatial resolution, estimate respiratory motion from fat images and measure T2*-related signal loss from the multi-echo images. Thus, perfusion quantification is improved by minimizing dark-rim artifacts, correcting for respiratory motion and T2*.

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