First-pass perfusion cardiac MR (FP-CMR) allows the detection of myocardial ischemia. Also, quantitative methods enable a reliable and operator-independent assessment of myocardial perfusion. However, conventional FP-CMR has limited spatial resolution and should be performed under breath-hold. Therefore, diagnostic accuracy is compromised by respiratory induced motion artifacts and false-positive defects due to dark-rim artifacts. We propose, a k-t accelerated dual-saturation FP-CMR multi-echo Dixon sequence to increase the spatial resolution, estimate respiratory motion from fat images and measure T2*-related signal loss from the multi-echo images. Thus, perfusion quantification is improved by minimizing dark-rim artifacts, correcting for respiratory motion and T2*.