Abstract #1318

Ferumoxytol contrast increases the normalized relative difference in T1 reactivity between remote and ischemic myocardium

Caroline M. Colbert^1,2, Anna Le³, Jiaxin Shao¹, Jesse Currier³, Peng Hu¹, and Kim-Lien Nguyen^1,2,3

¹Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ²Physics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ³Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

T1 reactivity can be used as a marker for myocardial perfusion reserve in the setting of ischemia or hypoperfusion. We hypothesize that ferumoxytol, as a pure intravascular agent with high r1 relaxivity, sensitizes T1 reactivity for assessment of myocardial perfusion. We selectively induced acute myocardial hypoperfusion in twelve healthy male Yorkshire swine. We then performed native and ferumoxytol-enhanced adenosine stress testing with the MOLLI sequence at 3.0T. Ferumoxytol increased absolute T1 reactivity in remote regions by 4.62-fold. The normalized difference in T1 was 4.5-fold greater in FE images compared to native T1.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.