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Abstract #1336

Towards Coronary Flow Reserve Assessment with 4D Flow MRI

Carmen PS Blanken1, Eva S Peper1, Lukas M Gottwald1, Bram F Coolen2, Gustav J Strijkers2, R Nils Planken1, Aart J Nederveen1, and Pim van Ooij1
1Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 2Biomedical Engineering, Amsterdam UMC, Amsterdam, Netherlands

Coronary flow reserve (CFR) is a clinical test that interrogates the function of the entire coronary vasculature, indicating the presence of coronary stenoses, microvascular disease or both in patients with ischemic heart disease. We used 15 times accelerated 4D flow MRI with compressed sensing reconstruction at an isotropic spatial resolution of 1.0 mm to measure diastolic flow in the left coronary artery of six healthy subjects. Mean diastolic flow was 1.15±0.18 ml/s with a mean scan-rescan difference of 0.06 ml/s. 4D flow MRI-based diastolic flow quantification in the LCA is feasible and could enable non-invasive CFR measurement.

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