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Abstract #1365

Transition Frequencies across the Brain States under Stress Differentiate Depression Vulnerability

Xue Zhang1,2, Hua Guo1, and Lihong Wang3
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Radiological Sciences Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, United States, 3Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, United States

Brain state transitions during resting-state reflect the variation of the baseline homeostasis, it is still unclear how the state interactions are modulated under stress. In the current study, the stress-induced change of the co-activation pattern transitions was examined in two independent cohorts by scanning resting-state fMRI pre- and post- a math task, its association with depression vulnerability was also explored. The post- versus pre-stress resting-state comparison showed an increased state transition frequency under stress, and those with higher depression scores shifted more post-stress in both cohorts, indicating the disturbed brain homeostasis under stress and lower recovery ability from stress.

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