Brain state transitions during resting-state reflect the variation of the baseline homeostasis, it is still unclear how the state interactions are modulated under stress. In the current study, the stress-induced change of the co-activation pattern transitions was examined in two independent cohorts by scanning resting-state fMRI pre- and post- a math task, its association with depression vulnerability was also explored. The post- versus pre-stress resting-state comparison showed an increased state transition frequency under stress, and those with higher depression scores shifted more post-stress in both cohorts, indicating the disturbed brain homeostasis under stress and lower recovery ability from stress.
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