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Abstract #1371

Decoupling of brain activity from connectome in multiple sclerosis and neuromyelitis optica

Chenfei Ye1, Jing Huang2, Haiyan Lv3, Jie Lu2, and Ting Ma1,4,5,6
1Department of Electronic and Information Engineering, Harbin Institute of Technology at Shenzhen, Shenzhen, China, 2Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, China, 3Shenzhen MindsGo Life Technology Co.Ltd, Shenzhen, China, 4Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China, 5Peng Cheng Laboratory, Shenzhen, China, 6National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China

Coupling of brain functional activity with brain structural network (connectome) plays a key role in cognition and movement. In this study, we anticipated that the structural-functional coupling would be altered in multiple sclerosis (MS) and neuromyelitis optica (NMO). By introducing the graph frequency analysis on diffusion and functional MR images, we found that brain activity in patient with both MS and NMO deviated from the underlying structural network, indicating disrupted structural-functional coupling caused by neuronal inflammation and demyelination.

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