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Abstract #1384

Cross-relaxation magnetic resonance imaging for multiple sclerosis

Jung-Jiin Hsu1, Jung-Yu C. Hsu2, and Roland G. Henry1
1Department of Neurology, University of California San Francisco, San Francisco, CA, United States, 2Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan, Taiwan

Magnetization transfer (MT) is of great interest in clinical and pre-clinical imaging to probe tissue properties that cannot be visualized directly with conventional MRI. Current research and development of MT MRI is based on the chemical exchange mechanism. However, it has long been reported that, instead of chemical exchange, the cross-relaxation mechanism is responsible for MT in biological tissue. In this work, a fast MRI method is developed based on cross relaxation for the measurement of the spin–lattice relaxation rate and the MT rate and is applied to characterize multiple sclerosis lesions.

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