Abstract #1386

Quantitative susceptibility of thalamus, basal ganglia and normal appearing white matter in multiple sclerosis

Gibran Manasseh¹, Mário João Fartaria^2,3,4, Tom Hilbert², Jérémy Deverdun⁵, Meritxell Bach Cuadra⁶, Philippe Maeder¹, Patric Hagmann¹, Tobias Kober², and Vincent Dunet¹

¹Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ²Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne; Siemens Healthcare AG; École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁵I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France, ⁶Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne; École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Quantitative susceptibility mapping is an emerging MRI technique that may provide additional information on brain tissue with potential applications in multiple sclerosis characterization and monitoring. However, the link between tissue susceptibility and disease evolution is not well known. This study investigates the relationship between basal ganglia, thalamus and normal appearing white matter susceptibility and lesion load, based on a fully automated pipeline for lesion and brain segmentation. Significant correlations were found between lesion load and susceptibility in putamen, thalamus, and white matter, presumably due to myelin loss in basal ganglia and iron loss in normal appearing white matter and thalamus.

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