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Abstract #1402

Reduced field-of-view multi-shell diffusion-weighted imaging of the sciatic nerve: Application to multiple sclerosis

Marios C. Yiannakas1, Francesco Grussu1,2, Marco Battiston1, Ratthaporn Boonsuth1, Rebecca S. Samson1, Torben Schneider3, Masami Yoneyama4, Ferran Prados1,5,6, Carmen Tur1, Sara Collorone1, Rosanna Cortese1, Olga Ciccarelli1, and Claudia A. M. Gandini Wheeler-Kingshott1,7,8
1Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 3Philips Healthcare, Guildford, Surrey, United Kingdom, 4Philips Japan, Minatoku, Tokyo, Japan, 5Centre for Medical Image Computing, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 6Universitat Oberta de Catalunya, Barcelona, Spain, 7Brain MRI 3T Research Centre, IRCCS Mondino Foundation, Pavia, Italy, 8Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

Ex vivo investigations have demonstrated the involvement of the peripheral nervous system in multiple sclerosis (MS). However, the use of advanced imaging methods to study individual peripheral nerves in vivo, such as the sciatic nerve, has been hindered by a number of technical challenges. In this pilot in vivo study, we explore the feasibility of acquiring multi-shell diffusion-weighted imaging (DWI) metrics in the sciatic nerve of people with relapsing-remitting MS (RRMS) using reduced field-of-view echo planar imaging. DWI metrics in people with RRMS display changes in comparison to healthy controls, suggesting that the structural integrity of the nerve is compromised.

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