Abstract #1408

Microstructure changes in secondary progressive multiple sclerosis measured using advanced quantitative MRI of the brain and spine

Marco Battiston¹, Carmen Tur^1,2, Marios C. Yiannakas¹, Francesco Grussu^1,3, Torben Schneider⁴, Daniele Martinelli⁵, Baris Kanber⁶, Ferran Prados^1,6,7, Patrizia Pajak¹, Olga Ciccarelli¹, Rebecca S. Samson¹, and Claudia A.M. Gandini Wheeler-Kingshott^1,8,9

¹NMR Research Unit, UCL Queen Square MS Centre, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ²Neurology Department, , Luton and Dunstable University Hospital, Luton, United Kingdom, ³Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ⁴Philips Healthcare, Guilford, United Kingdom, ⁵IRCCS Mondino Foundation, Pavia, Italy, ⁶Centre for Medical Image Computing, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁷Universitat Oberta de Catalunya, Barcelona, Spain, ⁸Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁹Brain MRI 3T Center, IRCCS Mondino Foundation, Pavia, Italy

Multiple Sclerosis (MS) is a complex disease whose mechanisms of progression still remain unclear. The use of quantitative MRI techniques in a multi-modal fashion, i.e. acquisition of more than one contrast type, can help to non-invasively measure changes in the tissue at a microstructural level during the disease course. Moreover, evidence of spinal cord involvement and its role in the diagnosis and prognosis is mounting. Here, we aim to address both needs by developing a multi-modal qMRI protocol for joint investigation of brain and spinal cord microstructure, and we report findings from a small cohort of people with MS.

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