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Abstract #1411

Pediatric-Onset Multiple Sclerosis: Imaging with Focus on Posterior Fossa Involvement

Laleh Eskandarian1,2, Bahadır Konuskan3, Hacer Dasgin2, Ismail Solmaz3, Rahsan Gocmen4, Banu Anlar4, and Kader Karli Oguz2,4
1Neuroscience Department, Bilkent University, Ankara, Turkey, 2National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 3Faculty of Medicine, Pediatric Neurology, Hacettepe University, Ankara, Turkey, 4Faculty of Medicine, Department of Radiology, Hacettepe University, Ankara, Turkey

Pediatric-onset-Multiple-Sclerosis (POMS) has been reported to have larger and higher number of T2 lesions as with more frequent posterior fossa involvement compared to adults. We aimed to analyze POMS patients morphological, microstructural alterations and their correlates with clinical characteristics with emphasis on posterior system. SUIT,Freesurfer and TBSS were used for spatialized parcellation, and analysis. Cerebellum except paramedian structures and cerebral cortices showed volume reductions, cerebral white matter and midbrain showed reduced FA and increased MD,AD,RD. Total and periventricular lesion loads, thalamic volumes showed correlations with special clinical metrics. Multiparametric brain MRI may reveal information on tissue changes and clinical correlates.

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