Pediatric-onset-Multiple-Sclerosis (POMS) has been reported to have larger and higher number of T2 lesions as with more frequent posterior fossa involvement compared to adults. We aimed to analyze POMS patients morphological, microstructural alterations and their correlates with clinical characteristics with emphasis on posterior system. SUIT,Freesurfer and TBSS were used for spatialized parcellation, and analysis. Cerebellum except paramedian structures and cerebral cortices showed volume reductions, cerebral white matter and midbrain showed reduced FA and increased MD,AD,RD. Total and periventricular lesion loads, thalamic volumes showed correlations with special clinical metrics. Multiparametric brain MRI may reveal information on tissue changes and clinical correlates.
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