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Abstract #1413

Cerebral vasoreactivity reveals white matter tracts alteration in multiple sclerosis patients with motor symptoms

François-Louis Collemiche1, Céline Charroud2, Aude Metzger3, Xavier Ayrignac4, Pierre Labauge4, Nicolas Menjot de Champfleur4, Emmanuelle Le Bars4, and Jérémy Deverdun4
1Neuroradiology, Hospital Gui de Chauliac, MONTPELLIER, France, 2Center for Mind/Brain Science, Rovereto, Italy, 3Hospital Pierre Wertheimer, Lyon, France, 4Hospital Gui de Chauliac, MONTPELLIER, France

One hypothesis in physiopathological mechanisms of multiple sclerosis (MS) involves astrocyte metabolism disruption as a consequence of axonal dysfunction, leading to cerebral vasoreactivity alterations (CVR). The aim was to explore a possible link between axonal tracts alterations and CVR disruption. 35 MS patients underwent MR. We selected motor clinical symptoms, and compared cerebral vasoreactivity and DTI maps. Both poCVR and DTI maps showed vasoreactivity alterations in white matter regions. Maps outlined the Inferior Fronto-Occipital Fasciculus in patients with “difficulties using upper limbs”. Vasoreactivity could be a new biomarker for assessing the evolution of white matter tracts’ alterations in MS follow-up.

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