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Abstract #1415

Combined 3D FLAIR and T2-weighted (FLAIR3) improves the detection of infratentorial lesions in multiple sclerosis

Refaat E Gabr1, John A Lincoln2, Arash Kamali1, Xiaojun Sun1, Khader M Hasan1, and Ponnada A Narayana1
1Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, United States, 2Neurology, University of Texas Health Science Center at Houston, Houston, TX, United States

Infratentorial lesions play an important role in the diagnosis of multiple sclerosis (MS), but are challenging to detect on conventional FLAIR protocols. Synthetic FLAIR3 images were generated by combining FLAIR and T2-weighted images to improve lesion contrast while maintaining CSF suppression. We evaluated FLAIR3 for detecting infratentorial lesions in 10 patients with MS. Our results show 11-fold increase in the lesion contrast-to-noise ratio and 163% increase in the number of detected lesions using FLAIR3 as compared to FLAIR.

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