Abstract #1448

Assessing the impact of age-related locus coeruleus degeneration on cognitive decline

Jason Langley¹, Sana Hussain², Justino J Flores³, Daniel E Huddleston⁴, Ilana Bennett³, and Xiaoping Hu^1,2

¹Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, United States, ²Bioengineering, University of California Riverside, Riverside, CA, United States, ³Psychology, University of California Riverside, Riverside, CA, United States, ⁴Neurology, Emory University, Atlanta, GA, United States

Characterization of age-related alterations in microstructure of locus coeruleus and its projections will aid in the development of new biomarkers and may provide insight in the development of novel interventions to arrest progression of Alzheimer's disease or Parkinson's disease. Imaging locus coeruleus with diffusion-weighted images is difficult due to its small stature (locus coeruleus is 1.5 mm in diameter and 15 mm long) and location in the brain stem. In this abstract, we utilize a high resolution diffusion-weighted protocol to examine age-related microstructural changes in locus coeruleus and examine its effect on age-related cognitive decline.

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