We have identified reduced cerebral blood flow, abnormally long mean transit time, and large capillary transit time heterogeneity in seven individuals with mild cognitive impairment or Alzheimer’s disease as compared to healthy subjects by using a highly accelerated dynamic susceptibility enhanced (DSC) MRI technique. This perfusion imaging technique provides whole brain coverage using simultaneous multi-slice acquisition and collects spin and gradient echo in one dynamic scan. The spin-echo and gradient-echo DSC-MRI acquisition enables probing and potentially distinguishing micro- and macro-vascular contributions to perfusion in older adults using a single injection of gadolinium.
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