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Abstract #1464

Perfusion Imaging of Patients with Alzheimer’s Disease by Using highly-accelerated Spin and Gradient Echo (SAGE) DSC-MRI

Yi-Fen Yen1, Mary Kate Manhard1, Annie G. Bryant2, Rachel E. Bennett2, Kimberly A. Stephens1, David H. Salat1,3, Keith A. Johnson2, Bradley T. Hyman2, Kawin Setsompop1, and Susie Huang1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, 3VA Boston Healthcare System, Neuroimaging Research for Veterans Center, Boston, MA, United States

We have identified reduced cerebral blood flow, abnormally long mean transit time, and large capillary transit time heterogeneity in seven individuals with mild cognitive impairment or Alzheimer’s disease as compared to healthy subjects by using a highly accelerated dynamic susceptibility enhanced (DSC) MRI technique. This perfusion imaging technique provides whole brain coverage using simultaneous multi-slice acquisition and collects spin and gradient echo in one dynamic scan. The spin-echo and gradient-echo DSC-MRI acquisition enables probing and potentially distinguishing micro- and macro-vascular contributions to perfusion in older adults using a single injection of gadolinium.

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