Abstract #1467

Quantitative susceptibility and R2* mapping in mild cognitive impairment and early Alzheimer’s disease

Catherine A Morgan^1,2, Zichang Dong³, David Lythgoe⁴, Lynette Tippett^1,2, and Tracy Melzer^5,6

¹School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand, ²Brain Research New Zealand, Auckland, New Zealand, ³Department of Physics, University of Auckland, Auckland, New Zealand, ⁴Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, ⁵University of Otago, Christchurch, New Zealand, ⁶Brain Reserach New Zealand, Christchurch, New Zealand

There is a growing body of work (post-mortem and in vivo) to support the link between iron and the pathophysiology of neurodegenerative disorders. While much of the current literature has focused on later stages of diseases such as Parkinson’s and Alzheimer’s disease (AD), how iron may contribute to early pathology is less well understood. We employed QSM and R2* mapping in a group of mild cognitive impairment and early AD subjects along with age-matched controls. Our pilot results suggest that magnetic susceptibility is higher in the cortex of the cognitively impaired group and is negatively correlated with cognition.

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