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Abstract #1481

Longitudinal assessment of brain iron deposition in Alzheimer’s disease

Christian Langkammer1, Anna Damulina1, Lukas Pirpamer1, Martin Soellradl1, Edith Hofer1,2, Christian Tinauer1, Maximilian Sackl1, Christian Enzinger1,3, Stefan Ropele1, and Reinhold Schmidt1
1Department of Neurology, Medical University of Graz, Graz, Austria, 2Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria, 3Department of Radiology, Medical University of Graz, Graz, Austria

Using R2* relaxation rate mapping we found higher iron concentrations in the deep grey matter and neocortical regions in 101 patients with Alzheimer’s disease compared to 101 age-matched community-dwelling individuals. AD patients had significantly higher R2* in the temporal and occipital lobes and caudate nuclei. Independently of brain volume loss, changes in cortical iron levels over time were associated with cognitive decline in participants with Alzheimer's disease.

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