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Abstract #1531

Patterns of regional cortical thinning in cognitively impaired patients with Parkinson’s disease

Shefali Chaudhary1, S Senthil Kumaran1, Vinay Goyal2, GS Kaloiya3, M Kalaivani4, NR Jagannathan1, Rajesh Sagar5, Nalin Mehta6, and Achal Srivastava2
1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, 3National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India, 4Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India, 5Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India, 6Department of Physiology, All India Institute of Medical Sciences, New Delhi, India

Cognitive impairment (CI) affects 20-40% Parkinson’s disease (PD) patients. Cortical thickness (CT), measuring the shortest distance between brain surface and inner edge of cortical gray matter may relate to CI in PD. In this study, we evaluated CT alteration in cognitively impaired PD patients (PD-CI) in comparison to cognitively normal (CN) healthy controls (HC) and PD patients (PD-CN) using 3DT1 MR data. Extended cortical thinning in frontal, temporal, parietal, occipital regions in PD-CI and significant positive association with global cognition MoCA score may signify cognition linked Lewy pathology and may be a promising tool to characterize cognition in PD.

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