Abstract #1531

Patterns of regional cortical thinning in cognitively impaired patients with Parkinson’s disease

Shefali Chaudhary¹, S Senthil Kumaran¹, Vinay Goyal², GS Kaloiya³, M Kalaivani⁴, NR Jagannathan¹, Rajesh Sagar⁵, Nalin Mehta⁶, and Achal Srivastava²

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, ³National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India, ⁴Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India, ⁵Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India, ⁶Department of Physiology, All India Institute of Medical Sciences, New Delhi, India

Cognitive impairment (CI) affects 20-40% Parkinson’s disease (PD) patients. Cortical thickness (CT), measuring the shortest distance between brain surface and inner edge of cortical gray matter may relate to CI in PD. In this study, we evaluated CT alteration in cognitively impaired PD patients (PD-CI) in comparison to cognitively normal (CN) healthy controls (HC) and PD patients (PD-CN) using 3DT1 MR data. Extended cortical thinning in frontal, temporal, parietal, occipital regions in PD-CI and significant positive association with global cognition MoCA score may signify cognition linked Lewy pathology and may be a promising tool to characterize cognition in PD.

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