Meeting Banner
Abstract #1533

Identification of potential saliva bio-markers in early and advanced Parkinson’s disease using high resolution NMR

Sadhana Kumari1, S.Senthil Kumaran1, Vinay Goyal2, Achal Srivastava2, SadaNand Dwivedi3, and N.R. Jagannathan1
1NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Neurology, All India Institute of Medical Sciences, New Delhi, India, 3Biostatistics, All India Institute of Medical Sciences, New Delhi, India

NMR-based metabolomics of saliva was studied in patients with Parkinson’s disease (PD) in early and advanced stages in comparison with that of healthy controls (HC). Higher levels of histidine, TMAO, propionate, GABA, valine, isoleucine, alanine, and fucose were observed in early PD in comparison with HC. Higher propionate and acetoin concentrations were observed in both early and advanced PD groups as compared to the HC group. An association of a few metabolites with the disease duration, LEDD and H&Y stage of PD patients was observed. Gut microflora system, ketone body and energy metabolisms may be impaired in patients with PD.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here