Abstract #1546

Exploration of mannitol-treated dehydration in acute stroke using diffusion kurtosis imaging with free water elimination

Chia-Wen Chiang¹, Ezequiel Farrher², Kuan-Hung Cho¹, Shih-Yen Lin^1,3, Kuo-Jen Wu⁴, Yun Wang⁴, Teh-Chen Wang⁵, Yi-Ping Chao⁶, Yeun-Chung Chang⁷, Chang-Hoon Choi², and Li-Wei Kuo^1,8

¹Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, ²Institute of Neuroscience and Medicine – 4, Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany, ³Department of Computer Science, National Chiao Tung University, Hsinchu, Taiwan, ⁴Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan, ⁵Department of Medical Imaging, Taipei City Hospital, Taipei, Taiwan, ⁶Department of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan, ⁷Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, ⁸Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan

Brain swelling typically occurs in acute stroke.¹ Mannitol, as a hyperosmolar agent, enables to effectively treat the increased intraocular pressure and cerebral edema in brain injury.^2,3 Diffusion kurtosis imaging with free water elimination (DKI-FWE)⁴ has been recently reported the ability to assess diffusion indices by separating free water compartment in simulations and healthy volunteers. The purpose of the study was to examine the effect of mannitol infusion using a stroke rat model at acute and chronic stages assessed by DKI-FWE and DKI. Our preliminary results revealed that mean kurtosis (MK) was sensitive to reflect mannitol-treated dehydration in acute stroke rat.

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