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Abstract #1546

Exploration of mannitol-treated dehydration in acute stroke using diffusion kurtosis imaging with free water elimination

Chia-Wen Chiang1, Ezequiel Farrher2, Kuan-Hung Cho1, Shih-Yen Lin1,3, Kuo-Jen Wu4, Yun Wang4, Teh-Chen Wang5, Yi-Ping Chao6, Yeun-Chung Chang7, Chang-Hoon Choi2, and Li-Wei Kuo1,8
1Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 2Institute of Neuroscience and Medicine – 4, Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany, 3Department of Computer Science, National Chiao Tung University, Hsinchu, Taiwan, 4Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan, 5Department of Medical Imaging, Taipei City Hospital, Taipei, Taiwan, 6Department of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan, 7Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 8Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan

Brain swelling typically occurs in acute stroke.1 Mannitol, as a hyperosmolar agent, enables to effectively treat the increased intraocular pressure and cerebral edema in brain injury.2,3 Diffusion kurtosis imaging with free water elimination (DKI-FWE)4 has been recently reported the ability to assess diffusion indices by separating free water compartment in simulations and healthy volunteers. The purpose of the study was to examine the effect of mannitol infusion using a stroke rat model at acute and chronic stages assessed by DKI-FWE and DKI. Our preliminary results revealed that mean kurtosis (MK) was sensitive to reflect mannitol-treated dehydration in acute stroke rat.

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