We explored the feasibility of applying Synthetic MRI to quantify leukoaraiosis and further investigated the association of leukoaraiosis with small vascular cerebral diseases and large vessel atherosclerosis in individuals with acute cerebral vascular symptom. The results show that LA could be evaluated by the volume and relaxation time from synthetic MRI and it was associated with lacune and cerebral microbleeds rather than large cerebral atherosclerosis. This finding suggests that quantitative information provided by Synthetic MRI can help to evaluate leukoaraiosis, and leukoaraiosis may be a type of cerebral small vascular diseases instead of intracranial or extracranial cerebral atherosclerosis.
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