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Abstract #1585

Detection of brain microstructural alterations in epilepsy using DTI and mean apparent propagator (MAP)-MRI

Weike Zeng1, Mengzhu Wang2, Xu Yan3, and Guang Yang4
1Deptpartment of Radiology, SUN YAT-SEN Memorial Hospital, SUN YAT-SEN University, Guangzhou, China, 2MR Scientific Marketing, Siemens Healthcare, Guangzhou, China, 3MR Scientific Marketing, Siemens Healthineers, Shanghai, China, 4Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China

We investigated the clinical feasibility of characterizing brain tissue microstructure in epilepsy with mean apparent propagator (MAP)-MRI, and compared with diffusion tensor imaging (DTI) using whole-brain voxel-based analyses. Results demonstrated that the MAP-MRI microstructural parameters could potentially provide more sensitive clinical biomarkers than conventional DTI techniques due to increased pathophysiological specificity in microstructural changes detection.

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