This study aimed to measure ischemic penumbra volumes using susceptibility-weighted imaging and mapping (SWIM). We compared the diagnostic accuracy between SWIvolume-diffusion-weighted imaging (DWI) and SWIASPECTS-DWI mismatches and analyzed the relationships among the SWIvolume-DWI, SWIASPECTS-DWI, and PWI-DWI mismatches and the different parameters and NIHSS. We found that quantitative SWIvolume-DWI mismatch volumes were more accurate than those of the SWIASPECTS-DWI mismatch in being able to evaluate ischemic penumbra. The asymmetrical prominent cortical vein volumes using SWIM showed hypoperfused regions and Tmax >6s volumes, based on perfusion-weighted imaging (PWI). The quantitative SWIvolume-DWI mismatch was highly consistent with the PWI-DWI mismatch.