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Abstract #1618

Angiogenesis following peripheral blood stem cell therapy: evidence from perfusion MRI of patients with ischemic stroke

Chao-Chun Lin1, Wen-Chau Wu2, Woei-Cherng Shyu3, Yi-Jui Liu4, Hing-Chiu Chang5, Yu-Chien Luo3, Der-Cherng Chen3, Chia-Wei Lin3, Hsiao-Wen Chung6, and Shinn-Zong Lin7
1Department of Radiology, China Medical University Hospital, Taichung, Taiwan, 2Institute of Medical Device and Imaging, National Taiwan University, Taipei, Taiwan, 3China Medical University Hospital, Taichung, Taiwan, 4Department of Automatic Control Engineering, Feng-Chia University, Taichung, Taiwan, 5Department of Diagnostic Radiology, University of Hong Kong, Hong Kong, Hong Kong, 6Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 7Buddhist Tzu Chi General Hospital, Hualien, Taiwan

Dynamic susceptibility-contrast perfusion-weighted MRI was performed on 15 chronic stroke patients receiving intracerebral implantation of peripheral blood stem cells (PBSC) at baseline and 6 longitudinal stages after therapy to derive relative cerebral blood volume around the implanted graft relative to contralateral white matter (rCBV ratio), with 15 control patients receiving baseline MRI plus two follow-ups. Nine of the 15 patients (60%) in the PBSC group showed significantly increased rCBV ratio than the baselines (1.39±0.60 versus 1.07±0.44; p < 0.01) at one week after implantation only, preceding functional improvements starting at one month as assessed by NIH stroke scale.

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