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Abstract #1638

Venous Oxygenation in Sickle Cell Patients and Controls using Quantitative Susceptibility Mapping versus T2-relaxation-under-spin-tagging  

Hanne A Stotesbury1, Russell Murdoch2, Patrick Hales1, Jamie M. Kawadler1, Melanie Kölbel 1, David Carmichael3, Chris A. Clark1, Fenella Kirkham1, and Karin Shmueli2
1Imaging and Biophysics, Developmental Nerosciences, UCL Great Ormond St Institute of Child Health, London, United Kingdom, 2Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 3Biomedical Engineering & Imaging Sciences, Kings College London, London, United Kingdom

In 15 homozygous sickle-cell disease patients (SCD; hemoglobin-SS) and 12 healthy controls (HC; 10 Hb-AA, 2 Hb-AS), we compared a quantitative susceptibility mapping (QSM)-based estimate of venous oxygen saturation (Yv) with T2-relaxation-under-spin-tagging (TRUST)-based estimates using bovine-hemoglobin (TRUST-HbBV), hemoglobin-S (TRUST-HbS), or hemoglobin-A (TRUST-HbA) calibrations. Agreement between methods varied, with QSM-Yv estimates in HC and SCD respectively on average 5-6% higher versus TRUST-HbBV, 5% higher and 9% lower versus TRUST-HbS, and 9% higher and 2% lower versus TRUST-HbA. Across all comparisons, the limits of agreement were wide (18-26%) underscoring the need for further studies comparing non-invasive methods with gold-standard jugular vein catheterization.

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