Abstract #1638

Venous Oxygenation in Sickle Cell Patients and Controls using Quantitative Susceptibility Mapping versus T2-relaxation-under-spin-tagging

Hanne A Stotesbury¹, Russell Murdoch², Patrick Hales¹, Jamie M. Kawadler¹, Melanie Kölbel ¹, David Carmichael³, Chris A. Clark¹, Fenella Kirkham¹, and Karin Shmueli²

¹Imaging and Biophysics, Developmental Nerosciences, UCL Great Ormond St Institute of Child Health, London, United Kingdom, ²Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ³Biomedical Engineering & Imaging Sciences, Kings College London, London, United Kingdom

In 15 homozygous sickle-cell disease patients (SCD; hemoglobin-SS) and 12 healthy controls (HC; 10 Hb-AA, 2 Hb-AS), we compared a quantitative susceptibility mapping (QSM)-based estimate of venous oxygen saturation (Yv) with T2-relaxation-under-spin-tagging (TRUST)-based estimates using bovine-hemoglobin (TRUST-HbBV), hemoglobin-S (TRUST-HbS), or hemoglobin-A (TRUST-HbA) calibrations. Agreement between methods varied, with QSM-Yv estimates in HC and SCD respectively on average 5-6% higher versus TRUST-HbBV, 5% higher and 9% lower versus TRUST-HbS, and 9% higher and 2% lower versus TRUST-HbA. Across all comparisons, the limits of agreement were wide (18-26%) underscoring the need for further studies comparing non-invasive methods with gold-standard jugular vein catheterization.

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