A bulk of research shows reduced cerebral blood flow is linked to thinning of the cortex and cognitive impairment in dementias and vascular disease while negative relations between functional connectivity and cognition in health are positive in HIV. Our findings of significantly increased CBF in the bilateral middle occipital gyri (MCG) while only left MCG negatively correlated with time for Stroop Color in HIV+ group might underpin that the transition from normal cognition to cognitive impairment in compensation for the abnormal structural and functional alterations. CBF values might reflect hemodynamic differences in HIV+ patients without signs of HIV-associated neurocognitive disorder.
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