Cerebral blood flow during awake and pharmacologically induced sleep was investigated with arterial spin labeling imaging in healthy young volunteers. Participants were scanned after a good night sleep and in a separate session after 24h sleep deprivation. Participant received 10mg Zolpidem after the sleep deprivation to maximize sleep in the scanner. There was a significant reduction in cerebral blood flow in the sleep condition compared to awake. The most prominent changes were observed in the Thalamus, cerebellum, posterior cingulate gyrus, these areas stayed significant after family wise error correction at a cluster level.