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Abstract #1673

Abnormality of insular functional connectivity in uremic restless legs:a resting state functional magnetic resonance study

DUN DING1,2, Xueying Ma2,3, Peng Li4, Pan Zhang5, and Ming Zhang6
1The Second affiliated hospital of Xi'an JiaoTong Uuniversity, Xi'an, China, 2The second affiliated hospital of Xi 'an JiaoTong Uuniversity, Xi'an, China, 3The First affiliated hospital of Neimenggu medical Uuniversity, Hohhot, China, 4The first affiliated hospital of Xi'an JiaoTong Uuniversity, Xi'an, China, 5The second affiliated hospital of Xi'an JiaoTong Uuniversity, Xi'an, China, 6The First affiliated hospital of Xi'an JiaoTong Uuniversity, Xi'an, China

Uremic Restless Leg Syndrome (uRLS) is an uncomfortable complication of inferior limbs and involuntary movements in patients with end-stage renal disease during maintenance of insular, especially during sleep breaks. As an important information processing and processing area, the insular play an important role in sensory, motor metabolism, sensorimotor information processing,and mood regulation. Through this study,We found that the altered morphology of post insular was revealed in uRLS patients, abnormal sensorimotor activities in patients with RLS is closely associated with reduced functional connectivity of insular-S1.Low hemoglobin level was the most important risk factor related to brain functional connectivity feature.

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