Uremic Restless Leg Syndrome (uRLS) is an uncomfortable complication of inferior limbs and involuntary movements in patients with end-stage renal disease during maintenance of insular, especially during sleep breaks. As an important information processing and processing area, the insular play an important role in sensory, motor metabolism, sensorimotor information processing,and mood regulation. Through this study,We found that the altered morphology of post insular was revealed in uRLS patients, abnormal sensorimotor activities in patients with RLS is closely associated with reduced functional connectivity of insular-S1.Low hemoglobin level was the most important risk factor related to brain functional connectivity feature.
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