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Abstract #1683

Venous disruption affects white matter integrity through increased interstitial fluid in cerebral small vessel disease

Ruiting Zhang1, Peiyu Huang1, and Minming Zhang1
1The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China

We aimed to investigate whether and how venous disruption was related to white matter damage in cerebral small vessel disease(CSVD) patients. SWI was used to investigate venous disruption. Free water elimination DTI model was used to analyze interstitial fluid fraction(fraction of free water, fFW) and white matter integrity(tissue fractional anisotropy, FAt). In 104 CSVD patients, venous disruption was associated with FAt, and the effect was mediated by fFW. This relationship was independent of arterial cerebral blood flow. In conclusion, we discovered the venous disruption - increased interstitial fluid - white matter damage link in CSVD patients.

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