Abstract #1685

Association of cerebral microbleeds and blood-brain barrier function in patients with different severity levels of dementia

Szu-Hsuan Yu¹, Wei-Chi Li¹, Jiun Wei Chen², Hong-Yuan Mark Liao², Feng-Chi Chang³, Chih-Ping Chung^4,5,6, Jong-Ling Fuh^6,7,8, and Li-Fen Chen^1,8,9,10

¹Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ²Institute of Information Science, Academia Sinica, Taipei, Taiwan, ³Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, ⁴Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan, ⁵Department of Neurology, National Yang Ming University, Taipei, Taiwan, ⁶Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ⁷Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, ⁸Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ⁹Integrated Brain Research Unit, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ¹⁰Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan

The contributions of blood vessels impairment to dementia are increasingly recognized, but the relationships between microbleeds and blood–brain barrier (BBB) in dementia patients are still unclear. We recruited subjects with Alzheimer’s disease (AD), mild cognitive impairment (MCI), subjective cognitive decline (SCD), and healthy control (HC). The susceptibility weighted images and dynamic contrast-enhanced images were acquired to detect cerebral microbleeds and to estimate BBB integrity. Our results showed high risk with BBB breakdown in AD patients with cerebral microbleeds, which suggests the association between neurovascular unit dysfunction and blood vessel impairment may be a biomarker for the progression of dementia.

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