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Abstract #1685

Association of cerebral microbleeds and blood-brain barrier function in patients with different severity levels of dementia

Szu-Hsuan Yu1, Wei-Chi Li1, Jiun Wei Chen2, Hong-Yuan Mark Liao2, Feng-Chi Chang3, Chih-Ping Chung4,5,6, Jong-Ling Fuh6,7,8, and Li-Fen Chen1,8,9,10
1Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 2Institute of Information Science, Academia Sinica, Taipei, Taiwan, 3Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, 4Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan, 5Department of Neurology, National Yang Ming University, Taipei, Taiwan, 6Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, 7Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, 8Brain Research Center, National Yang-Ming University, Taipei, Taiwan, 9Integrated Brain Research Unit, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, 10Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan

The contributions of blood vessels impairment to dementia are increasingly recognized, but the relationships between microbleeds and blood–brain barrier (BBB) in dementia patients are still unclear. We recruited subjects with Alzheimer’s disease (AD), mild cognitive impairment (MCI), subjective cognitive decline (SCD), and healthy control (HC). The susceptibility weighted images and dynamic contrast-enhanced images were acquired to detect cerebral microbleeds and to estimate BBB integrity. Our results showed high risk with BBB breakdown in AD patients with cerebral microbleeds, which suggests the association between neurovascular unit dysfunction and blood vessel impairment may be a biomarker for the progression of dementia.

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