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Abstract #1687

Investigating CSF Flow in Amnestic Mild Cognitive Impairment: A Preliminary Report

Arun Venkataraman1, F. Vankee Lin2, Rashid Deane3, and Jianhui Zhong4
1Physics, University of Rochester, Rochester, NY, United States, 2Neurology, University of Rochester, Rochester, NY, United States, 3Neuroscience, University of Rochester, Rochester, NY, United States, 4Imaging Sciences, University of Rochester, Rochester, NY, United States

Amnestic MCI (aMCI) is a prodromal stage to Alzheimer's Disease (AD), with around 10-15% of patients with aMCI converting to AD per year. It is unclear what mechanisms are involved in the initiation and progression through aMCI. One hypothesis involves the “glymphatic” system, a hypothesized pathway mediated by Cerebrospinal Fluid (CSF) flow that is essential to clearing toxins and cellular debris from the brain. In this study, we analyze how CSF flow dynamics are altered in subjects with aMCI. Overall, we found that lower flow in the 4th ventricle is linked with increased disease burden.

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