DCE-MRI was used to conduct quantitative analysis of microvascular permeability in three different areas of meningioma: Lesion, Edge and Normal. 37 patients with pathologically confirmed meningioma were enrolled, while quantitative parameters were measured. The parameters of ktrans, TTP, MAX. Conc, iAUC in Lesion group and Edge group were statistically significant, and the parameters of Ktrans, kep, Ve, TTP, Max.Conc as well as AUC in Lesion group and Normal group, were statistically significance. The ktrans parameter has the highest AUC value, which means the better performance for permeability study of WHO with different grades of meningiomas and invasive meningiomas.