In small intracranial melanoma metastases, MRI evidence of melanin was more common in BRAFV600-mutant patients than BRAF-wildtype, supporting that melanin content is greater in not just the primary, but also in the distant metastases. Haemorrhage and central necrosis were more common in larger metastases. Central necrosis was also more common in BRAF-mutant patients who had not previously received anti-BRAF therapy, suggesting that metastases in BRAF-mutant patients have a tendency to central necrosis, though this is modified by anti-BRAF therapy, thus resulting in more solid metastases.
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