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Abstract #1733

Assessment of Cerebello-Thalamo-Cortical (CTC) Fiber Pathways in Post-Surgical Medulloblastoma Patients Using a CTC Template  

Qing Ji1, Matthew Scoggins1, Angela Edwards1, John O. Glass1, Tara Brinkman2,3, Zoltan Patay1, and Wilburn E. Reddick1
1Diagnostic Imaging, St.Jude Children's Research Hospital, Memphis, TN, United States, 2Psychology, St.Jude Children's Research Hospital, Memphis, TN, United States, 3Epidemiology and Cancer Control, St.Jude Children's Research Hospital, Memphis, TN, United States

A CTC fiber pathway template was built in MNI space from the CTC data of 10 healthy controls. The template was aligned with the principle diffusion directions of each individual DTI data of additional 10 healthy controls and 11 post-surgical medulloblastoma patients using a linear algorithm developed in this study. The aligned template can accurately mimic the real CTC pathways in an individual subject in both healthy and post-surgical subjects. The DTI parameter values in post-surgical medulloblastoma patients can be accessed using the transformed CTC pathway.

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