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Abstract #1737

Along-tract quantitative analysis of arcuate fasciculus for awake glioma surgery

Lia Talozzi1, Matteo Martinoni2, Micaela Mitolo 3, Filippo Badaloni2, Sofia Asioli1,4, Claudia Testa5, Raffaele Lodi1,6, and Caterina Tonon1,3
1Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, 2IRCCS Istituto delle Scienze Neurologiche di Bologna, Neurosurgery Unit, Bologna, Italy, 3IRCCS Istituto delle Scienze Neurologiche di Bologna, Neuroradiology Functional Diagnostic Unit, Bologna, Italy, 4Section of Anatomic Pathology 'M. Malpighi', Bellaria Hospital, Bologna, Italy, 5Physics and Astronomy, University of Bologna, Bologna, Italy, 6, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

Probabilistic arcuate fasciculus (AF) tractography was computed in healthy controls (HC) and for a patient with a diffuse glioma, IDH 1 wild type left frontal lobe. Bilateral curvature mapping and along-tract DTI measures were evaluated, modelling surface geometry. In HC, hemispheric asymmetries in tract curvature showed a more lateral and inferior trajectory on the left, not measured for the patient’s left AF, medially dislocated. In HC, a left-lateralized asymmetries (higher FA and volume) was measured, and it was preserved for the patient. During pre-surgical evaluation, the proposed developed tractography analyses allowed a quantitative investigation of AF dislocation and microstructural integrity.

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