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Abstract #1741

Do targeted biopsies improve the correlation between ADC and cellularity in patients with glioma?

Simran Kukran1,2, Marianna Inglese2, Katherine L Ordidge2,3, Claire Davies 2, Lesley Honeyfield3, Babar L Vaqas4, Sophie Camp4, David Peterson4, Kevin O'Neill4, Clara Limback-Stanic5, Tara Barwick2,3, Adam Waldman6,7, and Matthew Grech-Sollars2,3
1Department of Radiotherapy and Imaging, Institute of Cancer Research, Sutton, United Kingdom, 2Department of Surgery and Cancer, Imperial College London, London, United Kingdom, 3Department of Imaging, Imperial College London, London, United Kingdom, 4Department of Neurosurgery, Imperial College London, London, United Kingdom, 5Department of Histopathology, Imperial College London, London, United Kingdom, 6Department of Medicine, Imperial College London, London, United Kingdom, 7Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom

It is thought that hypercellular regions of glioma have lower ADC values via a restriction in flow path, but there is no consensus regarding the correlation between ADC values and the cellularity of histological biopsies. In this study a slightly stronger negative correlation was observed between sample cellularity and the average ADC across the biopsy region as compared to the average ADC across the whole tumour in patients with glioma. However, neither correlation was found to be significant, which could be due to a small cohort size and the variation in tumour biological factors other than cellularity affecting ADC.

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