Abstract #1741

Do targeted biopsies improve the correlation between ADC and cellularity in patients with glioma?

Simran Kukran^1,2, Marianna Inglese², Katherine L Ordidge^2,3, Claire Davies ², Lesley Honeyfield³, Babar L Vaqas⁴, Sophie Camp⁴, David Peterson⁴, Kevin O'Neill⁴, Clara Limback-Stanic⁵, Tara Barwick^2,3, Adam Waldman^6,7, and Matthew Grech-Sollars^2,3

¹Department of Radiotherapy and Imaging, Institute of Cancer Research, Sutton, United Kingdom, ²Department of Surgery and Cancer, Imperial College London, London, United Kingdom, ³Department of Imaging, Imperial College London, London, United Kingdom, ⁴Department of Neurosurgery, Imperial College London, London, United Kingdom, ⁵Department of Histopathology, Imperial College London, London, United Kingdom, ⁶Department of Medicine, Imperial College London, London, United Kingdom, ⁷Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom

It is thought that hypercellular regions of glioma have lower ADC values via a restriction in flow path, but there is no consensus regarding the correlation between ADC values and the cellularity of histological biopsies. In this study a slightly stronger negative correlation was observed between sample cellularity and the average ADC across the biopsy region as compared to the average ADC across the whole tumour in patients with glioma. However, neither correlation was found to be significant, which could be due to a small cohort size and the variation in tumour biological factors other than cellularity affecting ADC.

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