The purpose of this study was to explore the diagnostic value of multimode diffusion imaging in the evaluation of glioma tumor grade and proliferation activity. (DKI) and MAP-MRImodel). The results showed that there were significant differences in MK, RTOP and QIV between high and low grade glioma, and the values of MK and QIV of the tumor parenchyma were positively correlated with ki-67. MK and QIV have great potential in predicting tumor proliferation activity. Multimode diffusion-weighted imaging is valuable for the evaluation of preoperative glioma grade and tumor proliferation activity.