While there is a growing trend for using volumetric acquisitions for brain MRI, long acquisition times still limit their adoption. There is still a tremendous need to reduce scan time of these volumetric acquisitions to improve workflow productivity and to reduce the likelihood of motion during the scan. MPRAGE sequence is a key 3D brain acquisition because of its excellent gray-white contrast which is ideal for visualization of substructures, segmentation and morphometric measurements. This work takes a rigorous quantitative approach to investigating the effects of compressed sensing and parallel imaging factors on various tissue measurements derived from accelerated MPRAGE images.
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