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Abstract #1766

Initial feasibility of a multi-band PSF-mapping based, reverse-gradient approach with geometric distortion correction for whole-brain fMRI

Myung-Ho In1, Daehun Kang1, Hang Joon Jo2, Uten Yarach1, Nolan K. Meyer1, Joshua D Trzasko1, Erin M Gray1, John III Huston1, Matt A Bernstein1, and Yunhong Shu1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2Department of Physiology, College of Medicine, Hanyang University, Seoul, Korea, Republic of

A point-spread-function mapping-based reverse-gradient approach was demonstrated as a viable method to correct severe susceptibility artifacts for deep-brain-stimulation fMRI in a pig model, but at the cost of reduced temporal resolution. Interleaved acquisition of the echo-planar-imaging was used with opposite phase-encoding polarities. In this work, feasibility was evaluated in in-vivo resting-state fMRI reliability in high-susceptibility regions. To compensate for the reduced temporal resolution, multi-band imaging was used, and the improved reliability in highly susceptible regions was evaluated on both standard whole-body and high-performance compact 3T scanners.

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