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Abstract #1781

Cerebral oxygen extraction fraction mapping: comparison of dual-gas challenge calibrated BOLD and challenge-free gradient echo QSM+qBOLD

Junghun Cho1, Yuhan Ma2, Pascal Spincemaille3, Bruce Pike2,4, and Yi Wang1,3
1Biomedical Engineering, Cornell University, New York, NY, United States, 2McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada, 3Radiology, Weill Cornell Medical College, New York, NY, United States, 4Radiology, University of Calgary, Calgary, AB, Canada

In this study, we compare cerebral oxygen extraction fraction (OEF) and metabolic rate of oxygen consumption (CMRO2) maps obtained using dual-gas challenge calibrated-BOLD (DGC) and challenge-free gradient echo quantitative susceptibility mapping plus quantitative blood oxygen level-dependent modeling (QSM+qBOLD or QQ) to explore the important clinical advantage of challenging-free data acquisition. In n=11 healthy subjects, cortical gray matter average OEF was not significantly different (36.4±1.9% and 38.0±9.1%, P=0.63) as was CMRO2 (151.4±17.6 and 168.2±54.1 μmolO2/min/100g, P=0.26), for QQ and DGC, respectively. QQ can measure OEF and CMRO2 at both baseline and hypercapnia independently, showing a 14% CMRO2 decrease in hypercapnia (P=0.039).

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